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10.1111/1523-1747.ep12358715 [DOI] [PubMed] [Google Scholar] 33.Litjens NH, Burggraaf J, van Strijen E, van Gulpen C, Mattie H, Schoemaker RC et al

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It is still unknown whether mutant SOD1 fibrils initiate ferroptosis by disrupting mitochondrial iron homeostasis, for example by promoting ironsulfur cluster release, or how lipid peroxidation products generated during ferroptosis (such as 4-HNE) accelerate TDP-43 nuclearcytoplasmic mislocalization and aggregation