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It is the pigment from the organism and not hemosiderin

Interaction of RAGE and HMGB1 leads to the phosphorylation of MAPKs and activation of the NF-B signaling pathway in macrophages, which stimulates the release of pro-inflammatory cytokines (e.g., TNF- and IL-1) by macrophages to promote tumor progression (Wen et al., 2019)