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Your health care provider needs to know if you have any of these conditions: kidney disease

In 1970, Orlowski and Meister proposed the -glutamyl cycle, which includes the synthesis, breakdown, export and import of GSH as a key process for amino acid uptake (Orlowski and Meister, 1970)

The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

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