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-Adrenergic Receptor Sensitivity: Potential secondary up-regulation of -AR expression, enhancing response to adrenergic stimuli

doi: 10.1056/NEJMra1713263 15 NaultJCNingarhariMRebouissouSZucman-RossiJ

Resistance mechanisms to anti-PD cancer immunotherapy

In isolated cardiomyocytes from rabbits and mice, treatment with empagliflozin inhibited NHE1 flux, reduced cytosolic Na + and Ca 2+ levels, and increased mitochondrial Ca 2+ levels, likely by direct binding of empagliflozin to NHE1 [143144]