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In addition, this treatment also downregulated Bcl-2, MDR-1, survivin, vimentin, CXCR4, IL-10, and PD-L1, while increasing the expression of FADD, APAF-1, caspase-3, IFN-, and E-cadherin in malignant cells [182]

To facilitate their broader clinical adoption, future research should focus on several strategic areas

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