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Furthermore, orthogonal partial least squares discriminant analysis (OPLS-DA) confirmed the significant separation between the groups, and the robustness of the created models was evaluated using 100-permutation test, yielding a model fitness (R 2 Y = 0.977) and predictive ability (Q 2 = 0.814) indicating excellent model performance (Fig

81-2261 of the MnO 2 crystal and JCPDS No

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This method allows for the targeted enrichment of particular EV subpopulations based on their unique surface markers, enhancing the purity and homogeneity of the isolated vesicles (Huang et al., 2021