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Economic Analysis Method Patients and Databases Population-based administrative databases for Ontario were used to identify patients receiving vitamin B12 (cobalamin) intramuscular injections in any fiscal year between 2006 and 2011

In the CNS, both neurons and glial cells express cGAS and STING, and their activation by mtDNA has been directly implicated in neuroinflammation and NDDs [12, 93]

A deficiency in vitamin B12 can lead to a type of anemia called pernicious anemia

Both studies were conducted in accordance with Good Clinical Practice, the Declaration of Helsinki and US Food and Drug Administration/European Medicines Agency guidelines for studies in people with renal or hepatic impairment Consent to Participate/Publish All participants provided written, informed consent