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Description

Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells

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Free Radic Res 2018;52:819-25

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Its core mechanisms involve dysregulated iron metabolism, excessive lipid peroxidation and compromised antioxidant defense (26)

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Moreover, increased cathepsin L expression in CC tissues correlates with poorer 5-year overall cumulative survival in CC patients (74)

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