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doi: 10.1038/nature06664 173 BillinghamLKStoolmanJSVasanKRodriguezAEPoorTASziborMet al

Direct administration bypasses the limitations of oral supplementation and delivers therapeutic levels where theyre needed most

Acknowledgement The patient in this manuscript has given written informed consent to the publication of his case details and photographs

Conway R, Low C, Coughlan RJ, ODonnell MJ, Carey JJ (2015) Risk of liver injury among methotrexate users: a meta-analysis of randomised controlled trials