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Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness

Our results demonstrated that CPT1A in tumor cells effectively restrains CD8 + T cell-induced tumor ferroptosis, which can be markedly suppressed by Fer1 or IFN neutralizing antibody in vitro (Fig

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ECs can also store large amounts of glucose in glycogen, which is mobilized in the event of glucose deprivation, and if the rate-limiting enzyme in glycogen degradation (glycogen phosphorylase) is inhibited, ECs migration and viability are impaired (Vizn et al., 2009)