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It is now, however, recognized that approximately 20% of patients with bronchiectasis also have significantly elevated sputum eosinophils and Th2 markers ( Figure 2 )

Finally, the third burst of ERK1/2 activation associated with G2/M progression 34 was also greatly diminished and associated with a reduced number of cells replicating DNA and progressing in G2 and M phases

NRF2 SUMOylation is mediated by a sequential enzymatic process involving the SUMO-activating enzyme E1, the SUMO-conjugating enzyme E2, and the SUMO ligase E3 [128]

doi: 10.1038/s41598-019-44513-8 33 Oliveira-de-SouzaDVinhaesCLArriagaMBKumarNPQueirozATLFukutaniKFet al