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P53 can inhibit cysteine uptake by downregulating SLC7A11, reducing GPX activity and GSH synthesis and subsequently causing intracellular ROS accumulation and ferroptosis (83)

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[DOI] [PubMed] [Google Scholar] Wu Z., Zhang X.Y., Wang H., Tang W., Xia Y., Zhang F., Liu J., Fu Y., Hu J., Chen Y., Liu L., Chen D.C., Xiu M.H., Kosten T.R., He J