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GLP-1 and GIP receptors are G-protein-coupled receptors expressed primarily in pancreatic beta cells, the hypothalamus, and the GI tract

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Moreover, the discovery of ghrelin O-acyltransferase (GOAT) as the enzyme that catalyzes ghrelin octanoylation, revealed several therapeutic possibilities including the design of drugs that inhibit GOAT and block the attachment of the octanoyl group to the ghrelin third serine residue