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FOX04 The curiously named Forkhead box O4, FOX04 , is a protein that is involved in regulating various cellular processes, including cell cycle arrest, apoptosis, DNA repair, stress response, metabolism, and longevity (Huang, 2021)

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47 A randomized placebo-controlled trial with 101 menopausal participants found a combination of 520 mg black cohosh, 400 mg chaste tree, 100 mg soy isoflavones, and 500 mg evening primrose oil, taken once daily for 12 weeks, improved hot flashes and sweating, sleep problems, mood, and irritability, as well as levels of C-reactive protein (CRP) (a marker of inflammation), LDL-cholesterol, and triglycerides

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