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In breast cancer cells, AGR2 expression decreases the degradation of HIF-1 and increases MDR1 transcription, thus decreasing epirubicin uptake and promoting doxorubicin ( DOX ) resistance in breast cancer cells 42

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Proc Natl Acad Sci 101:1477114775

then, the mesendodermal aggregates were hepatically specified for 5 days, resulting in the expression of AFP , CEBPa , HNF4, PROX1 , TBX3 , and TTR coinciding with decreased expression of DE markers such as HHEX , SOX17 and GATA4 (Supplementary Fig