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These findings laid the groundwork for the first human trial of AAV-mediated RNAi therapy, which reported a remarkable 45% reduction in HTT levels without inducing neuropathological abnormalities or adverse effects (McBride et al

The increased free iron pool generates ROS through the Fenton reaction (Dowdle et al., 2014)

3.3 Inflammation-induced immune cell activation Aberrant immune activation, occurring both within the CNS and throughout the bodys peripheral systems, contributes directly to the intertwined pathologies of EDC

doi: 10.14310/horm.2002.1276 [DOI] [PubMed] [Google Scholar] 89.Gupta RP, Verma PC, Garg SL