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Chronic ethanol exposure can activate the extrinsic apoptotic pathway in addition to the mitochondrial pathway

In addition, myelin structure becomes dysregulated particularly in the white matter, with myelin thickening, outfoldings, unravelling, enlargement of inner tongues 90,91,92

Specifically, the dithiol groups of Trx(SH) 2 can directly reduce oxidized proteins or provide electrons to thiol-dependent peroxidases (Prx) to convert hydrogen peroxide to water

On the other hand, an elevated concentration of homocysteine, and its metabolites such as homocysteine thiolactone and N-homocysteinyllysine result in health problems and has been indicated as an independent risk factor for cardiovascular disease and accelerated atherosclerosis