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Methods: Records of pediatric patients with BA who received MRX for at least 3 months through the CUP were retrospectively reviewed from five tertiary hospitals

Matrix metalloproteinases (MMPs), a class of metalloendopeptidase produced by tumor cells and supportive cells, allow for the degradation of the basement membrane as well as the extracellular matrix surrounding pre-existing capillaries, typically postcapillary venules [30, 31]

This was one of the best healthcare appointments I have ever had: Quick response times Phone call with the geneticist before committing to the appointment 2+ hours spent with the geneticist & his resident Full genealogy & clinical assessment A compassionate listening ear & no interruptions A diagnosis that involved him looking me straight in the eyes & saying Maggie, you do have hypermobility Ehlers-Danlos Syndrome

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