glutathiones role in eye Restoring Glutathione Homeostasis Glycation-Related Diseases: Mechanistic Insights and Therapeutic Interventions Beyond VEGF Inhibition Glutathione - an overview |

Studies have shown that long-term use of metformin may be associated with B12 deficiency

338 The accumulation of ROS further exacerbates cellular stress by inducing genotoxic damage, which can lead to overactivation of the p53 tumor suppressor gene, driving persistent senescence and amplifying inflammatory signaling through increased cytokine and metalloproteinase production, potentially accelerating the onset or progression of RA and other age-related inflammatory conditions

However, sun exposure, hormonal changes, lifestyle factors and genetics can trigger recurrence

Proc Natl Acad Sci USA 99:517522 Tuzet A, Rahantaniaina MS, Noctor G (2019) Analyzing the function of catalase and the ascorbateglutathione pathway in H 2 O 2 processing: insights from an experimentally constrained kinetic model