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While Nrf2 and JAK2/STAT3 have protective roles, severe oxidative stress can also lead to their dysregulation or interaction with other pathways in ways that contribute to later-stage remodeling or inflammation (Mahdiani et al., 2022

AL-MSC arrested their growth (number of harvested cells number of plated cells) at significantly earlier passages (p=0.049) compared to HD-MSC [median P2 (range 2-7) vs P11 (range 5-16), respectively]