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Additionally, the ethane group linker and the amino group of -alanine form the same interaction as that of taurine with hTauT: the two-carbon linker is nested into the subsites C lined by the hydrophobic side chain of L134 and Y138 on TM2, F300, A303, and L306 on TM6, and the amino group of -alanine also forms a hydrogen bond with the side chain of E406 on TM8 and water-mediated interactions with the main chain carboxylate group of F300 on TM6 and the side chain of Q403 on TM8 (Fig

The ability of cancer cells to prevent apoptosis via increased ROS formation requires increased antioxidant defense, such as increased transcription of genes encoding thioredoxin (TXN)- and glutathione (GSH)-dependent enzymes, as well as other detoxification and antioxidant enzymes (Fig

Folic acid is essential for DNA synthesis

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