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GSH-dependent redox control also extends to mitochondrial dynamics

567,568,569 They also regulate efflux transporter activity, as seen with lncRNA linc00518 sponging miR-199a to affect ABCC1 expression, causing doxorubicin resistance in breast cancer cells

The FINs ML-162, GPX inhibitor 26a, and PACMA31 at 10 M were able to increase intracellular rhodamine 123 fluorescence over 10-fold in Conclusion: Expression of P-gp may reduce the efficacy of these FINs in cancers that express the transporter and may prevent access to sanctuary sites such as the brain

FIGURE 3 4 Robust synergistic therapy against cancer 4.1 Sensitized chemotherapy As a chemotherapeutic agent, platinum is one of the most widely used metal-based anticancer components (Makovec, 2019)