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Secondary Signaling Beyond the pituitary, its binding to receptors in the hypothalamus results in the orexigenic effect (intense hunger signaling) and the suppression of somatostatin , ensuring that the growth hormone pulse is not prematurely inhibited by the bodys "off-switch" hormone

10.1016/j.jep.2025.120441 105 XiaS.LiL.ShiZ.SunN.HeY

Glaucoma involves progressive optic nerve damage, leading to distinct structural alterations in the optic disc and retinal nerve fibers, accompanied by progressive RGC death, which will be specifically discussed later

To construct a user-friendly prognostic tool, the rms package was employed to create a nomogram based on the multivariate Cox regression model, visually representing the contribution of each independent prognostic factor to the prediction of 1-, 3-, and 5-year overall survival