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At the same time, the authors of these publications pointed out that the full RXR agonist may have numerous side effects

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doi: 10.3390/nu12082395 Adaikalakoteswari et al Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes Clin Epigenetics

During somatic cell reprogramming, vitamin C-mediated removal of histone modifications such as H3K4me3 and H3K36me3, potentially by KDM5 and KDM2, respectively, can turn off the expression of genes, while demethylation of H3K9me2/me3 by members of the KDM3/4/7 family can remodel heterochromatin regions that can facilitate DNA hypomethylation at these otherwise silenced loci (Li et al., 2009