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The cobalt deficiency was overcome by the development of "cobalt bullets", dense pellets of cobalt oxide mixed with clay given orally, which then was retained in the animal's rumen

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(2) DHODH: DHODH is a mitochondrial flavoprotein localized to the inner mitochondrial membrane, where it catalyzes the fourth and rate-limiting step of de novo pyrimidine biosynthesisthe oxidation of dihydroorotate to orotate 42,43