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Description

Human CD157 shows predominantly expression within the myelomonocytic lineage, particularly in monocytes, neutrophils, and myeloid stages

Impaired GPX4 function plays a role in tumorigenesis, neurodegeneration, infertility, inflammation, immune disorders, and ischemia-reperfusion injury

doi:10.1089/ars.2017.7014

Its primary function is G-actin sequestration TB4 binds monomeric actin with nanomolar affinity, regulates the polymerizable actin pool, and indirectly governs cytoskeletal dynamics during cell migration, wound healing and inflammatory response