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Laboratory protocols should include appropriate controls and monitoring strategies to distinguish between beneficial elimination of harmful senescent cells and potential adverse effects on beneficial senescent cell populations

Medical Record Documentation Providers must document both: The medically necessary E/M service The procedure performed Documentation must support the medical necessity of using Modifier-25 Documentation need not be submitted with the initial claim but should be maintained for potential review Claims Processing Guidelines Current Claims When submitting claims with Modifier-25: Documentation must justify both services E/M service must be separately identifiable Modifier-25 must be appended to the E/M code Prior Claims Carriers will not retroactively recover payments for previously processed claims