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A comprehensive analysis of the mitochondrial metabolic processes that may facilitate ferroptosis, in addition to the mitochondrial defense systems (most notably GPX4) was recently conducted [127]

Natural antioxidants are widely found in food materials and medicinal plants and exert numerous biological effects ranging from anti-aging, anticancer, and anti-inflammation to anti-atherosclerosis

While EAE models have offered valuable insight into adaptive immune responses, demyelination, and axonal damage in MS, they fall short in replicating the full spectrum of human MS pathology, particularly the disease's onset and heterogeneity (Figure 5)

Research indicates that endogenous growth hormone secretion declines substantially with aging, with levels at age 70 approximately 60% lower than at age 20