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Melanin synthesis in melanocyte or melanoma cells is mainly regulated by the MC1R/MITF/tyrosinase-signaling pathway. Journal of Advanced Pharmaceutical Technology & Research, 2020 Link to study When melanocytes downregulate this pathwayeither due to aging, oxidative stress, or genetic predispositionthe result is melanin depletion and visible gray or white hair , clinically referred to as canities