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MARCHETTI, M., TESTONI, S

10.1007/s00204-021-03211-z 8 AkakpoJ

Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

The principal epigenetic mechanisms observed in human cells encompass DNA methylation, posttranslational modifications of histones, and the involvement of non-coding RNA molecules, including microRNAs and long non-coding RNAs