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Sam West, postdoctoral researcher12, Jadine Scragg, postdoctoral researcher12, Paul Aveyard, professor123, Jason L Oke, departmental lecturer1, Lia Willis, research assistant1, Stella J P Haffner, research assistant1, Heather Knight, research assistant1, Danni Wang, research fellow1, Sarah Morrow, clinical doctoral fellow1, Laura Heath, clinical doctoral fellow1, Susan A Jebb, professor124, Dimitrios A Koutoukidis, associate professor12 1 Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK 2 National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, UK 3 National Institute for Health Research, Oxford Health Biomedical Centre, Warneford Hospital, Oxford, UK 4 National Institute for Health Research Applied Research Collaboration, Oxford University Hospitals NHS Foundation Trust, Oxford, UK Correspondence to: S West sam phc.ox.ac.uk (or @_WestSam on X) Accepted 6 November 2025 Abstract Objectives To quantify and compare the rate of weight regain after cessation of weight management medications (WMMs) in adults with overweight or obesity