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Manganese (Mn) has been shown to be a naturally occurring trace element that is essential for human health and development, but is neurotoxic at high concentrations (41,42)

A common feature of many of these neurotoxic compounds, such as rotenone, paraquat, or MPTP, is the inhibition of mitochondrial complex I, followed by the overproduction of ROS, ATP exhaustion, and induction of a wide range of abnormalities that can elicit neuronal and astrocytic cell death [54]

Glutathion rduit (GSH) en glule standard ou S-actyl glutathion, dos 250-500 mg/jour

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair