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Description

Apoptosis in Alzheimers disease: an understanding of the physiology, pathology and therapeutic avenues

Ferreira et al

doi: 10.1016/j.nlm.2012.02.008

While limited in scope, this investigation supports that interaction with the conserved T336 residue is a key component of inhibition at the CoA binding site and is a shared feature among structurally distinct uncompetitive inhibitors of Cn Acs1