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Yuen MF, Lim YS, Yoon KT, et al

Concomitant use of riociguat, a guanylate cyclase stimulator

A study found that DMF exerted neuroprotective effects through the crosstalk between Nrf2 and NF-B pathways in vitro and in vivo, besides regulating antioxidant enzymes such as Nrf2, Mn-SOD, and HO-1, thereby reducing the levels of pro-inflammatory cytokines such as IL-1 and iNOS (Campolo et al., 2017)