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Supplementary Figure S1A)

The recommended dosage for COBANERVE-B12 nasal spray is typically one spray in each nostril once daily

Schematic representation of the relationship between tyramine dose exposure and the severity of clinical responses, particularly in individuals with impaired tyramine metabolism such as those receiving monoamine oxidase inhibitor (MAOI) therapy

Oxidative-stress and autophagy Excessive oxidative stress and altered redox signaling are most commonly known to be involved in cell death signaling cascades