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Although there are studies showing that bFGF improves the biomechanical function of healed tendons, opposite researches have disproved this conclusion ( FIGURE 3 Since growth factors have a short half-life in the body, repeated injections of growth factors are required, which is more time-consuming and laborious, so some delivery vehicle for growth factors is needed to enable their sustained release, such as scaffolds in tissue engineering (Zhao et al., 2014)

The study protocol was reviewed and approved by the University of Tokyo Graduate School of Medicine EC (Serial number: 2020421NI)

2 A family history compatible with autosomal recessive inheritance is supportive

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