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Second, we will explore the potential value of these active ingredients in clinical applications, such as their use as dietary supplements for cancer prevention or as adjuvant therapy in conjunction with conventional therapies, and analyze the current challenges

Under conditions of oxidative stress, NRF2 associates with Keap1 and activates the expression of downstream target genes containing AREs, such as ferric heavy chain proteins (FTH1) and ferric light chain proteins (FTL), which encourages GSH synthesis and regenerates NADPH to compete with ROS production (83)

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Recombinant human Long-R 3 IGF-I (Cat no 143045-27-6) was obtained from Sigma-Aldrich (Saint Louis, USA) (Fig 1)