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Chronic hyperammonemia in vivo impairs long-term potentiation in hippocampus by altering activation of cyclic GMP-dependent-protein kinase and of phosphodiesterase 5

Psychiatry 23 , 56 (1960)

Studies in Parkinsons disease models show ghrelin, via GHS-R1a activation, reduces dopaminergic neuron loss, microglial activation, and pro-inflammatory molecules like TNF-alpha and IL-1beta