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Development and optimisation of alternative methods and approaches Main gaps identified: high rate of misleading/false genotoxic positives Existing in vitro methods, whilst having a high sensitivity (and thus low false negative rate), have a relatively low specificity and thus high rate of false (misleading) positive results, which typically has led to unnecessary follow-up testing in vivo for the confirmation of these results

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J Neurochem (1999) 73:2149.10.1046/j.1471-4159.1999.0730214.x 101 MunozAReyPGuerraMJ