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Often after damage to the intestinal epithelium, colonization with opportunistic pathogens occurs, and commensal abundance and biodiversity begins to decline [40, 41, 43,44,45, 52]

These clinical activities are referenced within the peer-reviewed preclinical literature rather than reported as standalone pivotal-trial publications

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Through this technique, chromatin modification allows transcription factors to reach genes, thereby enabling access to initiate processes of expression (114)