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In some embodiments, the invention encompasses use of one or more NNMT inhibitors for muscular therapy comprising contacting one or more cells with one or more NNMT inhibitors

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GLP-1 agonists (semaglutide, tirzepatide) reduce appetite and slow gastric emptying to create caloric deficits, while AOD-9604 and 5-Amino-1MQ directly enhance fat mobilisation and oxidation without affecting satiety signalling

fortunately, serious consequences are rare