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Therefore, some clients may need more frequent injections due to increased vitamin B12 utilization or loss

210,216,217 A randomized placebo-controlled trial in 100 heart disease patients found 450 mg of pomegranate extract plus 180 mg vitamin E (as synthetic dl-alpha tocopherol) daily for eight weeks reduced expression of two vascular adhesion proteins and lowered levels of inflammatory markers

Consider these evidence-based dietary strategies: Eat small, frequent, low-fat meals that are easier to digest Limit sugar alcohols (sorbitol, mannitol, xylitol) found in sugar-free products, which have known laxative effects Gradually increase soluble fiber through foods like oatmeal and psyllium supplements, which can help bulk stools Avoid excessive insoluble fiber from raw vegetables and whole grains during acute episodes Stay adequately hydrated with water and electrolyte-containing beverages to prevent dehydration Avoid spicy, greasy, or very high-fiber foods during episodes of diarrhea Medication dosing may require adjustment

DACRA KBP-088 and KBP-042 improved body weight, glycemic control and adipose hypertrophy in high-fat diet-fed rats (205)