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doi: 10.4161/auto.21315 147 LamasBVergnaud-GauduchonJGoncalves-MendesNPercheORossaryAVassonMPet al

MCI patients showed a decrease in GSH/GSSG ratios and GST activity in the hippocampus compared to healthy age-matched controls [86]

In particular, the post-radiotherapy evolution of the spectral changes associated with Cho compounds is predictive of tumour response: patients with increasing Cho/NAA values during radiotherapy were more likely to progress early [95] while Cho reduction at 2 months post-radiotherapy provide prognostic information regarding progression-free and overall survival [96]

Collectively, these findings indicate that astaxanthin supports synaptic plasticity through coordinated functional, structural, and molecular mechanisms, providing a mechanistic basis for its reported cognitive benefits ( 3 Biochemical and molecular mechanisms in AD Alzheimers disease is considered a neurodegenerative disorder that is progressive and mainly affects cognition, such as disrupting memory, learning, and decision-making