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This exchange is stimulated by the presence of high extracellular concentrations of OA 7 and is driven by the electrochemical gradient of GSH across the plasma membrane

For example, primaquine is safely given to individuals with the G6PD A variant, provided it is started cautiously (15 mg/day or 45 mg once or twice weekly) and the blood count is monitored closely

Whether the deglutathionylation requires a release or reorientation of the GSSR intermediate should depend on whether the four sulfur atoms of the disulfide substrate, GSH, and the active-site cysteinyl residue can be arranged like beads on string

We use experimentally determined forms for these allosteric interactions but sometimes the details of the kinetics are not known, forcing us to make reasonable educated guesses