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In vivo administration significantly increases serum testosterone levels in aged mice, accompanied by elevated expression of key testosterone synthesis enzymes including 3-HSD and CYP11A1

Likely because the concentration is high (e.g

11 Methionine synthase reductase ( MTRR ) Methionine synthase reductase or MTRR is another important enzyme that keeps B12 in its active form, which is methylcobalamin

[115] This functionality is lost in vitamin B 12 deficiency, resulting in an increased homocysteine level and the trapping of folate as 5-methyl-tetrahydrofolate, from which THF (the active form of folate) cannot be recovered