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Existing research indicates that long-term use of lipophilic statins can reduce the incidence of PD [168], likely by inhibiting microglial activation and decreasing the accumulation of inflammatory mediators and -syn, thereby attenuating neuroinflammation [169]

However, weight loss-induced AT inflammation could be a temporary process to restore tissue homoeostasis, and the inflammatory phenotype might be resolved upon prolonged lifestyle interventions or persistent weight maintenance 12,13,51

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