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Figure 3 6.1 Airway remodeling in asthma and impact of PM Airway remodeling in asthma is characterized by structural changes in the airway, including loss of epithelial barrier function, goblet cell hyperplasia, deposition of ECM components in the sub-epithelial reticular basement membrane, lamina propria, and submucosa of the airway epithelium, and increased airway smooth muscle (ASM) mass