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This allows more immediate access to the central nervous system (CNS) and systemic circulation

In humans with disseminated cryptococcosis, these capsular products are associated with decreased expression of L-selectin (CD62L) on the neutrophil surface, thereby reducing neutrophil migration

Meanwhile, dose change of sorafenib was in correlation with the occurrence of adverse events (141), so the combination of sorafenib with chemotherapy drugs should be further explored in large-scale cohort studies

Studies suggest the compound may enhance the brain's intrinsic capacity for repair through mobilization of existing plasticity mechanisms rather than requiring exogenous cell replacement therapies