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Adjusting protocols based on results When to extend protocol Extend if : Making progress but not complete (60-70% healed, goal is 90%) Results plateaued but could improve with more time No side effects, tolerating well Can afford extension How to extend : Add 4-8 weeks to original timeline May need to order more supplies Continue same doses unless adjusting Example : Planned 8 weeks BPC-157 , at week 8 injury 70% healed

Compared to previously established LSM based cutoff values of 10.5 kPa (Youden index) and 13.3 kPa (maximized specificity), the false positive rates of sequential covering analysis was 1% compared to 16.5% with LSM 10.5 kPa and 8.3% with LSM 13.3 kPa

British Journal of Cancer, 89 (3), 519523

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