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Clinical implications From the first inhaled insulin clinical programme by Inhale Therapeutics (later Nektar) in partnership with Pfizer (later Sanofi-Aventis), based on an air-gun device technology, to the porous particle-based technology developed by Alkermes and Eli Lilly, impressive advances in optimizing particle aerodynamics have led to deeper lung deposition and efficient systemic absorption

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It can cause headaches, pain in the joints, fever, eye pain, blindness, and even stroke

The echocardiography examination indicated that HUA mice showed increased left ventricular anterior and posterior wall thickness in the diastolic-stage, and posterior wall in the systolic-stage, while the thickening could be ameliorated by LC and AP intervention